The observed variation in the calcification responses of coccolithophores to changes in carbonate chemistry paints a highly incoherent picture, particularly for the most commonly cultured "species", <i>Emiliania huxleyi</i>.The disparity between magnitude and potentially even sign of the calcification change under simulated end-of-centu
Natural Compounds from Saffron and Bear Bile Prevent Vision Loss and Retinal Degeneration
All retinal disorders, regardless of their aetiology, involve the activation of oxidative stress and apoptosis pathways.The administration of neuroprotective factors is crucial in all phases of the pathology, even when vision has been completely lost.The retina is one of the most susceptible tissues to reactive oxygen species damage.On the other ha
Neuropsychiatric Systemic Lupus Erythematosus Is Dependent on Sphingosine-1-Phosphate Signaling
About 40% of patients with systemic lupus erythematosus experience diffuse neuropsychiatric manifestations, including impaired cognition and depression.Although the pathogenesis of diffuse neuropsychiatric SLE (NPSLE) is not fully understood, loss of brain barrier integrity, autoreactive antibodies, and pro-inflammatory cytokines are major contribu
Semi-Supervised Density Peaks Clustering Based on Constraint Projection
Clustering by fast searching and finding density peaks (DPC) method can rapidly identify the centers of clusters which have relatively high densities and high distances according to a decision graph.Various methods have been introduced to extend the DPC model over the past five years.DPC was originally presented as an unsupervised learning algorith